Also known as: Dehydroepiandrosterone, Prasterone, 5-Dehydroepiandrosterone
DHEA (dehydroepiandrosterone) is the most abundant circulating steroid hormone in the human body and a precursor to both testosterone and estrogen. Levels peak in early adulthood and decline steadily with age, prompting interest in supplementation for anti-aging and vitality.
DHEA (dehydroepiandrosterone) is a steroid hormone produced primarily by the adrenal glands, with smaller amounts produced in the gonads and brain. It serves as a critical precursor for the biosynthesis of androgens and estrogens. DHEA levels peak between ages 20 and 30 and decline by approximately 10% per decade thereafter, a process termed 'adrenopause.' This age-related decline has led to the hypothesis that DHEA supplementation may counteract various aspects of aging. Clinical research has shown benefits for bone mineral density in older women, adrenal insufficiency, and certain aspects of mood and well-being. However, as a prohormone, DHEA carries meaningful regulatory and safety considerations. In the United States, DHEA is sold as a dietary supplement, but in Germany, the EU, Canada, Australia, and many other countries, it is classified as a prescription hormone or controlled substance. DHEA supplementation can alter downstream sex hormone levels and is banned by the World Anti-Doping Agency (WADA). Individuals should consult a physician and have baseline hormone levels tested before considering supplementation.
A 12-month randomized trial showed that 50 mg/day DHEA significantly improved lumbar spine bone mineral density in older women by increasing IGF-1 and estrogen levels.
In patients with adrenal insufficiency, DHEA replacement therapy has been shown to improve energy, mood, sexuality, and overall quality of life in multiple controlled trials.
DHEA is enzymatically converted to testosterone and estradiol in peripheral tissues. Supplementation in older adults can raise levels of these downstream hormones, though the clinical significance of this increase remains debated.
Once daily in the morning to mimic natural circadian rhythm
Baseline DHEA-S blood levels should be measured before starting. Requires periodic monitoring of DHEA-S, testosterone, and estrogen levels. Prescription-only in Germany, the EU, and many other jurisdictions.
Optimal absorption and standardized dosing
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