Also known as: Tanacetum parthenium, Bachelor's Buttons, Featherfew
Feverfew is a traditional European medicinal herb primarily used for migraine prevention. Its active compound parthenolide inhibits serotonin release and inflammatory mediators involved in migraine pathogenesis.
Feverfew (Tanacetum parthenium) is a short perennial plant of the daisy family (Asteraceae) with a long history of use in European folk medicine, particularly for fevers, headaches, and arthritis. Its primary bioactive constituent is parthenolide, a sesquiterpene lactone that inhibits the release of serotonin from platelets, blocks NF-kB activation, and reduces production of pro-inflammatory prostaglandins and leukotrienes. Several randomized controlled trials have demonstrated modest reductions in migraine frequency and severity with daily prophylactic use, though results have been somewhat inconsistent. The Canadian and European regulatory authorities recognize feverfew as a traditional remedy for migraine prevention. A stable, standardized extract is essential for clinical benefit.
A Cochrane review found that feverfew reduced migraine frequency compared to placebo in several trials, though effect sizes were modest and some studies had methodological limitations.
Parthenolide is a potent NF-kB inhibitor and suppresses pro-inflammatory cytokine production, which contributes to both its migraine-preventive and general anti-inflammatory effects.
Once daily, consistently over several months
Minimum 4–6 weeks needed for preventive effects. Do not stop abruptly; taper gradually to avoid rebound headaches.
Migraine prophylaxis with guaranteed parthenolide content
Higher parthenolide concentration and stability
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