Also known as: Hypoxanthine Riboside, Hypoxanthosine
Inosine is a purine nucleoside involved in ATP metabolism and uric acid production. It has been investigated for neuroprotective effects in multiple sclerosis and Parkinson's disease, as well as athletic performance enhancement, though clinical evidence remains limited.
Inosine is an endogenous purine nucleoside formed during the breakdown of adenosine and serves as a precursor to uric acid via the enzyme xanthine oxidase. Interest in inosine supplementation stems from two main areas: its potential as a neuroprotectant through elevation of serum urate (a potent endogenous antioxidant), and its role in purine salvage pathways that support ATP regeneration in muscle tissue. The SURE-PD clinical trial investigated inosine's ability to raise serum urate levels in Parkinson's disease patients, based on epidemiological observations that higher urate levels correlate with slower disease progression. While inosine successfully elevated urate, the phase 3 SURE-PD3 trial did not confirm clinical benefit. In sports performance, inosine has been marketed as an ergogenic aid, but controlled studies have generally failed to demonstrate improvements in aerobic capacity or strength. A key safety consideration is that inosine increases uric acid levels, potentially precipitating gout or kidney stones in susceptible individuals.
Inosine raises serum urate, a potent natural antioxidant. Epidemiological data link higher urate levels to lower risk of Parkinson's disease, though the interventional SURE-PD3 trial did not confirm slowed disease progression.
As a purine nucleoside, inosine participates in the purine salvage pathway that recycles ATP precursors. Theoretical support for enhanced energy metabolism exists, but controlled exercise studies have not demonstrated significant ergogenic benefits.
Divided into 2–3 doses with meals
Doses in clinical trials were titrated to achieve target serum urate levels. Regular monitoring of uric acid levels is recommended. Not suitable for individuals with gout or kidney stone history.
Standardized dosing for supplementation
No product recommendations yet.
No reviews yet. Be the first to share your experience!