Also known as: PS, Ptd-L-Ser
Phosphatidylserine is a phospholipid essential for neuronal cell membrane integrity and signaling. It is one of the few supplements with an FDA-qualified health claim for reducing cognitive decline risk.
Phosphatidylserine (PS) is an aminophospholipid concentrated in the inner leaflet of neuronal cell membranes, where it plays critical roles in cell signaling, apoptosis regulation, and neurotransmitter release. The brain contains about 60 grams of PS, making it the most abundant phospholipid in neural tissue. Supplementation with PS has been shown to improve memory, attention, and language skills in aging adults with cognitive decline. In 2003, the FDA authorized a qualified health claim stating that PS may reduce the risk of cognitive dysfunction in the elderly. Originally derived from bovine brain cortex, modern PS supplements are typically sourced from soy or sunflower lecithin for safety reasons. PS also has documented effects on reducing exercise-induced cortisol, making it of interest for stress management and sports nutrition.
Multiple clinical trials demonstrate PS supplementation improves short-term memory, name-face recognition, and word recall in elderly subjects with age-associated memory impairment.
Phosphatidylserine supplementation at 400–800 mg has been shown to blunt the cortisol response to intensive exercise by 20–30%, reducing catabolic stress.
With meals, preferably in 2–3 divided doses
Most clinical trials use 300 mg daily (3 × 100 mg). Effects typically observed after 6–12 weeks.
Before exercise or divided throughout the day
Higher doses used specifically for blunting the cortisol response to exercise.
Standard supplementation at affordable cost
Allergen-free alternative to soy-derived PS
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