Also known as: Quercetin dihydrate, Quercetin glycoside
Quercetin is a ubiquitous plant flavonoid with potent antioxidant, anti-inflammatory, and senolytic properties. Clinical research supports its use for allergy relief, cardiovascular protection, and exercise endurance enhancement.
Quercetin is one of the most abundant dietary flavonoids, found in onions, apples, berries, and tea. It exerts broad biological effects through multiple mechanisms: it stabilizes mast cells and inhibits histamine release, providing natural antiallergic activity; it scavenges reactive oxygen species and upregulates endogenous antioxidant enzymes via Nrf2 activation; and it inhibits NF-κB, reducing production of pro-inflammatory cytokines IL-6 and TNF-α. Quercetin has gained attention as a senolytic agent that selectively eliminates senescent cells, particularly when combined with dasatinib, representing a promising longevity intervention. Meta-analyses show quercetin supplementation significantly reduces systolic blood pressure in hypertensive individuals. It also inhibits COMT and phosphodiesterase, mildly enhancing catecholamine and cAMP signaling for improved exercise capacity. Native quercetin has poor bioavailability (1–2%), but phytosomal and glycosylated forms significantly improve absorption.
Quercetin stabilizes mast cells and inhibits histamine release, reducing allergy symptoms such as sneezing, itching, and nasal congestion. Clinical studies show significant improvement in allergic rhinitis symptoms.
A meta-analysis of 7 RCTs found quercetin supplementation (≥500 mg/day) significantly reduced systolic blood pressure. It also reduces LDL oxidation and improves endothelial function.
Quercetin selectively induces apoptosis in senescent cells, particularly in combination with dasatinib. Preclinical studies show improved healthspan, reduced inflammation, and delayed age-related decline.
Divided into 2 doses with meals containing fat
Use phytosomal or liposomal forms for improved absorption. Take with vitamin C to enhance stability and uptake.
Once or twice daily with meals
Blood pressure benefits observed in studies using ≥500 mg/day for at least 8 weeks.
Maximum bioavailability and clinical efficacy
Affordable option for higher-dose protocols
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