Browse our comprehensive directory of evidence-based supplement profiles.
Herbs
Grape seed extract is a potent source of oligomeric proanthocyanidins (OPCs), polyphenolic compounds with strong antioxidant properties. It is widely studied for cardiovascular protection and its ability to support vascular integrity.
Adaptogens
Astragalus is a foundational herb in Traditional Chinese Medicine, prized for its immune-enhancing, anti-aging, and cardioprotective properties. Modern research has focused on its polysaccharides and cycloastragenol, the latter being studied for its potential to activate telomerase.
Schisandra chinensis is a traditional adaptogenic berry used in Chinese and Russian medicine. Its lignans, particularly schisandrin B, support liver function, enhance stress resilience, and improve mental performance under fatigue.
Hibiscus (Hibiscus sabdariffa) is a flowering plant whose calyces are rich in anthocyanins and organic acids. It is best known for its clinically supported blood-pressure-lowering effects and has a long tradition as a tart, ruby-colored herbal tea.
Licorice root (Glycyrrhiza glabra) contains glycyrrhizin and flavonoids with anti-inflammatory, antiviral, and adrenal-supportive properties. It is widely used in traditional medicine but requires caution due to its potential to raise blood pressure through mineralocorticoid activity.
Maritime pine bark extract, commonly sold as Pycnogenol, is a potent source of procyanidins with strong antioxidant and anti-inflammatory properties. It is clinically studied for cardiovascular support, improved microcirculation, and skin health.
Olive leaf extract contains oleuropein, a polyphenol with potent antioxidant, antihypertensive, and antimicrobial properties. Clinical evidence supports its use for blood pressure reduction and cardiovascular protection.
Nootropics
Piracetam is the original nootropic, a cyclic derivative of GABA developed in the 1960s. It is widely studied for its effects on cognitive function, memory, and cerebral blood flow.
Tongkat Ali (Eurycoma longifolia) is a Southeast Asian medicinal root studied for its testosterone-supporting, ergogenic, and adaptogenic properties. Clinical trials demonstrate improvements in male hormonal profiles, physical performance, and stress resilience.
Nettle root (Urtica dioica) is traditionally used to support urinary tract health and prostate function. Clinical research suggests it may help manage symptoms of benign prostatic hyperplasia (BPH) and modulate inflammatory pathways.
Andrographis paniculata is a bitter herb widely used in Ayurvedic and traditional Chinese medicine for immune support. Its primary bioactive compound, andrographolide, has demonstrated anti-inflammatory, antiviral, and immunomodulatory properties in clinical trials.
Capsaicin is the pungent compound in chili peppers, acting on TRPV1 receptors to modulate pain signaling. It is clinically established as a topical analgesic for neuropathic pain and arthritis, and emerging evidence supports its metabolic and cardiovascular benefits when consumed orally.
Amino Acids
Glutathione is the body's most abundant endogenous antioxidant, a tripeptide composed of glutamate, cysteine, and glycine. It plays a critical role in neutralizing free radicals, detoxifying xenobiotics, and supporting immune function.
Probiotics
Bifidobacterium longum is a foundational member of the human gut microbiome from birth. It supports digestive comfort, immune balance, and emerging research links it to stress and mood regulation via the gut-brain axis.
Pygeum bark extract (Prunus africana) is widely used in Europe for managing symptoms of benign prostatic hyperplasia (BPH). It contains phytosterols and pentacyclic triterpenes that support urinary tract function and reduce prostatic inflammation.
Methionine is an essential sulfur-containing amino acid that initiates protein synthesis and serves as the precursor to SAMe, cysteine, and taurine. It plays key roles in methylation, detoxification, and antioxidant defense.
Minerals
Boron is a trace mineral that supports bone metabolism, hormone regulation, and cognitive function. While not yet classified as an essential nutrient, emerging evidence suggests it plays important roles in calcium and magnesium metabolism.
Feverfew is a traditional European medicinal herb primarily used for migraine prevention. Its active compound parthenolide inhibits serotonin release and inflammatory mediators involved in migraine pathogenesis.
Fatty Acids
CLA is a group of naturally occurring trans fats found in ruminant meat and dairy. It has been studied for body composition improvement, particularly reducing body fat while preserving lean mass.
Phosphorus is the second most abundant mineral in the body, essential for bone formation, energy metabolism via ATP, and DNA/RNA synthesis. Most adults obtain adequate phosphorus from diet, making supplementation rarely necessary.